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Guide We were looking for phages generating a stable fiber with specificity to the E. coli O87 type O-antigen that allows the phage to grow on E. coli HS3-104 host cells.
Guide The structure resembles the receptor-binding tip from the bacteriophage T4 long tail fiber yet showing marked differences in its domain organization, size, sequence identity and metal binding
Guide Bacteriophage lambda is an excellent model system to study the tail architecture of bacteriophages. Wang et al. present the cryo-EM structures of the components of the bacteriophage
Guide Abstract The tail fibres of long-tailed phages are complex elongated protein assemblies capable of specific recognition of bacteria during the first step of viral infection. Correct assembly of these
Guide Here, we introduce RBPseg, a method that combines monomeric ESMFold predictions with a structural- based domain identification approach, to divide tail fiber sequences into
Guide The phage lambda gene J protein (CFP) forms the central fiber at the tail''s distal tip that binds lambda''s outer membrane protein receptor, LamB (Clement et al., 1983); J protein may also
Guide In this review, we discuss what is known about the detailed structure and function of the different long tail fiber domains. Partial crystal structures of gp34 and gp37 have revealed the presence of new
Guide Despite the wide occurrence of Tfa proteins, their functional mechanism has not been elucidated. Here, we investigate the tail fibre and Tfa of Escherichia coli phage Mu.
Guide Structurally these viruses have a prolate icosahedral capsid (the head) attached at one vertex to a long protein infection promoting structure (the tail) (Figure 2-1). At the far end of the tail are one or more
Guide The precise arrangement of amino acids in the receptor-binding domain of the tail fiber determines which bacterial surface molecules it can recognize, thereby defining the phage''s ability to
Guide Here we present the crystal structure of the receptor-binding tip of the bacteriophage T4 long tail fiber, which is highly homologous to the tip of the bacteriophage lambda side tail fibers.
Guide Recent significant advances at single-molecule and atomic levels have begun to unravel the structural organization of tail fibers and underlying mechanisms of phage–host interactions.
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